Monday, 20 July 2015

Marijuana Withdrawal Syndrome


There are now several clinical trials showing that mice and dogs show evidence of cannabis withdrawal. (For THC-addicted dogs, it is the abnormal number of wet-dog shakes that give them away.) Today, scientists have a much better picture of the jobs performed by anandamide, the body’s own form of THC. This knowledge helps explain a wide range of THC withdrawal symptoms.

Among the endogenous tasks performed by anandamide are pain control, memory blocking, appetite enhancement, the suckling reflex, lowering of blood pressure during shock, and the regulation of certain immune responses.

These functions shed light on common hallmarks of cannabis withdrawal, such as anxiety, chills, sweats, flu-like physical symptoms, and decreased appetite. At Columbia University’s National Center on Addiction and Substance Abuse, where a great deal of National Institute for Drug Abuse (NIDA) funded research takes place, researchers have found that abrupt marijuana withdrawal leads to symptoms similar to depression and nicotine withdrawal.



What the NIDA has learned about cannabis addiction, according to the principal investigator of a recent NIDA study, was that “we had no difficulty recruiting dozens of people between the ages of 30 and 55 who have smoked marijuana at least 5,000 times. A simple ad in the paper generated hundreds of phone calls from such people.” (This would be roughly equivalent to 14 years of daily pot smoking.)

There are now several clinical trials showing that mice and dogs show evidence of cannabis withdrawal. (For THC-addicted dogs, it is the abnormal number of wet-dog shakes that give them away.) Today, scientists have a much better picture of the jobs performed by anandamide, the body’s own form of THC. This knowledge helps explain a wide range of THC withdrawal symptoms.

Among the endogenous tasks performed by anandamide are pain control, memory blocking, appetite enhancement, the suckling reflex, lowering of blood pressure during shock, and the regulation of certain immune responses. These functions shed light on common hallmarks of cannabis withdrawal, such as anxiety, chills, sweats, flu-like physical symptoms, and decreased appetite. 

At Columbia University’s National Center on Addiction and Substance Abuse, where a great deal of National Institute for Drug Abuse (NIDA) funded research takes place, researchers have found that abrupt marijuana withdrawal leads to symptoms similar to depression and nicotine withdrawal.

What the NIDA has learned about cannabis addiction, according to the principal investigator of a recent NIDA study, was that “we had no difficulty recruiting dozens of people between the ages of 30 and 55 who have smoked marijuana at least 5,000 times. A simple ad in the paper generated hundreds of phone calls from such people.” (This would be roughly equivalent to 14 years of daily pot smoking.)



Here is a sampling of comments from dependent marijuana smokers, gathered from my blog, Addiction Inbox :

Comment 1

I’m 55 and I’ve been smoking pot off and on for the last 30 years… I had no idea of the withdrawal I would experience. Two days in, I thought for sure I had some dreaded disease. One minute I would be freezing, the next sweating. The loss of appetite doesn’t bother me because pot always helped me keep on an extra 5-10 lbs from the munchies and sweet tooth. Not sure how long it will take, but I do look forward to the day when this has all passed.

Comment 2

As far as symptoms, the worst for me so far has been insomnia, on day nine I was awake for 28 hours, a hallucinatory experience itself….The temperature regulation thing is very real, I’m freezing, I’m burning, I’m sweating. Starting to get hungry once a day.

Comment 3

The cravings have pretty much subsided but not completely. When I get bored is when it is the strongest. I have experienced the sweating, severe diarrhea, migraine headaches and sleeplessness…. I have hidden this addiction from family for so long and it’s nice to not have to worry if someone is going to stop by and smell it and catch me.

Comment 4

I have been smoking pot since I was 17, I am now 34, happily married with a child. I smoked at least once a day, up to 4 joints a day by myself. I stopped smoking a week ago but I am completely miserable…. I am always dreaming of using, I wake up in sweats and search the whole house for a roach sometimes when I am desperate but at the same time I feel proud that I have not called my dealer or visited my using friends, this time I might as well do it.

Comment 5

It’s been 2 weeks since I vaporized my last bowl, and since then I’ve gotten so desperate I’ve been smoking resin. Last night I used rubbing alcohol to get the resin out of my bong and smoked the resin after the alcohol evaporated. It tasted awful and barely got me high, but tonight I did it again, and I was so impatient that I put the resin-alcohol solution in the oven to help it evaporate! This is how desperate I’ve become – I’ve risked burning down my house in order to get marginally high.


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